منابع مشابه
The Regulation of Calcium Homeostasis in T Lymphocytes
Calcium is an important messenger in every cell type. Its intracellular level is regulated by finely tuned machinery responsible for calcium uptake, release, and intracellular storage. T cells are no exception in this regard. Pathways of calcium homeostasis participate in a number of cellular processes that determine short and long-term function of T lymphocytes. Over the recent year, an increa...
متن کاملMitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes
Mitochondria act as potent buffers of intracellular Ca2+ in many cells, but a more active role in modulating the generation of Ca2+ signals is not well established. We have investigated the ability of mitochondria to modulate store-operated or "capacitative" Ca2+ entry in Jurkat leukemic T cells and human T lymphocytes using fluorescence imaging techniques. Depletion of the ER Ca2+ store with t...
متن کاملWhole-cell recording of calcium release-activated calcium (CRAC) currents in human T lymphocytes.
In T lymphocytes, depletion of Ca(2+) from the intracellular Ca(2+) store leads to activation of plasmalemmal Ca(2+) channels, called Calcium Release-Activated Calcium (CRAC) channels. CRAC channels play important role in regulation of T cell proliferation and gene expression. Abnormal CRAC channel function in T cells has been linked to severe combined immunodeficiency and autoimmune diseases. ...
متن کاملCalcium-dependent potentiation of store-operated calcium channels in T lymphocytes
The depletion of intracellular Ca2+ stores triggers the opening of Ca2+ release-activated Ca2+ (CRAC) channels in the plasma membrane of T lymphocytes. We have investigated the additional role of extracellular Ca2+ (Ca02+) in promoting CRAC channel activation in Jurkat leukemic T cells. Ca2+ stores were depleted with 1 microM thapsigargin in the nominal absence of Ca02+ with 12 mM EGTA or BAPTA...
متن کاملFluoxetine suppresses calcium signaling in human T lymphocytes through depletion of intracellular calcium stores.
Selective serotonin reuptake inhibitors, such as fluoxetine, have recently been shown to exert anti-inflammatory and immunosuppressive effects. Although the effects on cytokine secretion, proliferation and viability of T lymphocytes have been extensively characterized, little is known about the mechanism behind these effects. It is well known that Ca(2+) signaling is an important step in the si...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1992
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)35689-8